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Volume : 26  Issue : 3  Year: 2020

A Case of Lennox-Gastaut Syndrome Who Developed Tonic Status Epilepticus Induced by Intravenous Diazepam [Epilepsi]
Epilepsi. 2012; 18(3): 38-42 | DOI: 10.5505/epilepsi.2012.63935  

A Case of Lennox-Gastaut Syndrome Who Developed Tonic Status Epilepticus Induced by Intravenous Diazepam

Murat Mert Atmaca, Betül Baykan, Nerses Bebek, Candan Gürses, Ayşen Gökyiğit
Department Of Neurology, Istanbul University, Istanbul, Turkey

Lennox-Gastaut syndrome (LGS) is an epileptic encephalopathy characterized by several types of seizures, special EEG patterns, and cognitive deterioration with resistance to therapy and poor prognosis. It is a well known phenomenon that some antiepileptic drugs (AED) have a worsening effect on some seizure types, especially in the generalized epilepsies of childhood. However, its underlying pathogenetic mechanisms are not fully understood. In this paper, a case with LGS who developed tonic status epilepticus induced by diazepame given intravenously is reported and the topic of seizure aggravation caused by AED and LGS is discussed.

Keywords: Lennox-Gastaut Sendrom, seizure exacerbation, diazepame


Lennox-Gastaut Sendromunda İntravenöz Diazepam ile Tetiklenen Tonik Status Epileptikus

Murat Mert Atmaca, Betül Baykan, Nerses Bebek, Candan Gürses, Ayşen Gökyiğit
İstanbul Üniversitesi İstanbul Tıp Fakültesi, Nöroloji Ana Bilim Dalı, İstanbul

Lennox-Gastaut Sendromu (LGS) çok sayıda nöbet tipinin birlikte görüldüğü, özel EEG paternlerine sahip, kognitif etkilenmenin de olduğu, tedaviye dirençli ve kötü prognozlu bir epileptik ensefalopatidir. Bazı antiepileptik ilaç (AEİ)’lerin, özellikle çocukluk çağının jeneralize epilepsilerinde, bazı nöbet tiplerini kötüleştirici etkisi iyi bilinen bir fenomendir; ancak bunun altında yatan patogenetik mekanizmalar tam olarak anlaşılmış değildir. Bu makalede, LGS tanısı ile izlenen, intravenöz diazepam ile tonik status epileptikusa giren bir olgu bildirilmiş, LGS ve AEİ’lere bağlı nöbet kötüleşmesi konusu tartışılmıştır.

Anahtar Kelimeler: Lennox-Gastaut Sendromu, nöbet kötüleşmesi, diazepam


Murat Mert Atmaca, Betül Baykan, Nerses Bebek, Candan Gürses, Ayşen Gökyiğit. A Case of Lennox-Gastaut Syndrome Who Developed Tonic Status Epilepticus Induced by Intravenous Diazepam. Epilepsi. 2012; 18(3): 38-42

Corresponding Author: Murat Mert Atmaca, Türkiye


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